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654256-M

Millipore

TNF-α Inhibitor

The TNF-α Inhibitor, also referenced under CAS 1049741-03-8, controls the biological activity of TNF-α.

Synonym(s):

TNF-α Inhibitor, Tumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor, 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl

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About This Item

Empirical Formula (Hill Notation):
C32H32F3N3O2 · 2HCl · 0.5H2O
CAS Number:
1049741-03-8
Molecular Weight:
629.54
UNSPSC Code:
51111800

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

DMSO: 10 mg/mL

storage temp.

−20°C

General description

A cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
A cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).

Biochem/physiol Actions

Primary Target
TNF-α
Target IC50: 22 µM for non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

He, M.M., et al. 2005. Science310, 1022.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

654256-5MG:
654256-MG:
654256-1.1ML:
654256-5MG-M:

Certificates of Analysis (COA)

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