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6.18300

Sigma-Aldrich

Acetonitrile

for chromatography (gradient grade 2.5)

Synonym(s):

Acetonitrile, ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

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About This Item

Linear Formula:
CH3CN
CAS Number:
75-05-8
Molecular Weight:
41.05
Beilstein:
741857
MDL number:
MFCD00001878
UNSPSC Code:
12191502
grade:
for chromatography (gradient grade 2.5)
technique(s):
HPLC: suitable
application(s):
general analytical
bp:
81-82 °C (lit.)
vapor pressure:
72.8 mmHg ( 20 °C)

grade

for chromatography (gradient grade 2.5)

Quality Level

100

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

Assay

≥99.9% (GC)

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

technique(s)

HPLC: suitable

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

solubility

water: soluble (1,000 g/l at 25 °C (77 °F))

density

0.786 g/mL at 25 °C (lit.)

application(s)

general analytical

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

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General description

Acetonitrile is commonly used as a key component in the mobile phase for gradient elution chromatography. It is used in various chromatographic techniques, such as high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS).

Application

Acetonitrile can be used as a mobile phase:
  • Buffer in the liquid chromatographic method for determination of polyamines, amino acids, metanephrines, and catecholamine compounds in human body fluids.
  • Component to facilitate the fast gradient elution separations of polar neutral active pharmaceutical ingredients (APIs).

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

IN26183002500:
IN26183001000:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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