Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

605197

Sigma-Aldrich

Thrombin-Activatable Fibrinolysis Inhibitor, Human

The Thrombin-Activatable Fibrinolysis Inhibitor, Human controls the biological activity of Thrombin-Activatable Fibrinolysis. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonym(s):

Plasma Procarboxypeptidase B, TAFI

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352202
NACRES:
NA.25

Quality Level

100

Assay

≥95% (SDS-PAGE)

form

liquid

specific activity

2-9 units/mg protein

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

shipped in

wet ice

storage temp.

−70°C

General description

Native thrombin-activatable fibrinolysis inhibitor from human liver. Single chain glycoprotein synthesized in the liver. ctivated by the thrombin/thrombomodulin complex by proteolytic cleavage at Arg92. Circulates in plasma as a zymogen at a concentration of about 50 nM. Believed to play an important role in the interaction between procoagulant, anticoagulant, and fibrinolytic systems.
Native thrombin-activatable fibrinolysis inhibitor from human liver. Single chain glycoprotein synthesized in the liver. Circulates in plasma as a zymogen at a concentration of 50 nM. Activated by thrombin-thrombomodulin complex by proteolytic cleavage at Arg92. Believed to play an important role in interaction between the procoagulant, anticoagulant, and fibrinolytic systems.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Unit Definition

One unit is defined as the amount of enzyme that will hydrolyze 1 µM Hip-L-Arg per min at 25°C, pH 7.65.

Physical form

In 150 mM NaCl, 20 mM HEPES, pH 7.4.

Preparation Note

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Boffa, M.B., et al. 1999. Biochemistry 38, 6547.
Boffa, M.B., et al. 1998. J. Biol. Chem. 273, 2127.
Bajzar, L., et al. 1995. J. Biol. Chem. 270, 14477.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

605197-50UG:
605197-UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service