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Safety Information

575001

Sigma-Aldrich

α-Synuclein, Human, Recombinant, E. coli

Synonym(s):

NACP

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

Quality Level

100

recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

suitability

suitable for molecular biology

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... SNCA(6622)

General description

Research area: Neuroscience

Recombinant, human α-synuclein expressed in E. coli. α-Synuclein is an acidic neuronal protein of 140 amino acids (amino acid residues 1 -140).

Application

α-Synuclein, Human, Recombinant, E. coli has been used to enhance the filter trap assay for identification of aggregated alpha-synuclein in brain samples.

Biochem/physiol Actions

α-Synuclein been implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 100 mM NaCl, 20 mM Tris-HCl, 1 mM MgCl₂, pH 7.5.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Kahle, P.J, et al. 2001. Am. J. Pathol.159, 2215.
Kim, J. 1997. Mol. Cells7, 78.
Paik, S.R. 1997. Arch. Biochem. Biophys.344, 325.
Jakes, R., et al. 1994. FEBS Lett.345, 27.
Ueda, K., et al. 1993. Proc. Natl. Acad. Sci. USA90, 11282.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

575001-UG:
575001-200UG:
970749-1MG:
970749-0UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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