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494460

Millipore

Octyl β-D-glucopyranoside

ULTROL® Grade, ≥99% (TLC), non-ionic detergent to solubilize membrane-bound proteins in their native state

Synonym(s):

n-Octyl-β-D-glucopyranoside, ULTROL® Grade, OG, n-Octylglucoside

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About This Item

Empirical Formula (Hill Notation):
C14H28O6
CAS Number:
29836-26-8
Molecular Weight:
292.37
MDL number:
MFCD00063288
UNSPSC Code:
12161902
NACRES:
NA.21

Quality Level

100

Assay

≥99% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

aggregation number

84

impurities

≤0.05% n-octanol

color

white

CMC

20 - 25 mM

solubility

water: 100 mg/mL

shipped in

ambient

storage temp.

15-25°C

InChI

1S/C14H28O6/c1-2-3-4-5-6-7-8-19-14-13(18)12(17)11(16)10(9-15)20-14/h10-18H,2-9H2,1H3/t10-,11-,12+,13-,14-/m1/s1

InChI key

HEGSGKPQLMEBJL-RKQHYHRCSA-N

General description

A highly purified nonionic detergent intended for solubilizing membrane-bound proteins in their native state, and for the preparation of lipid vesicles. Its well-defined chemical structure, small uniform micelles, and high water solubility make it superior to most other nonionic detergents for membrane solubilization. Because of its high critical micelle concentration (20-15 mM), it has the additional advantage of being removed easily by dialysis when compared to bile salts. Aggregation number: 84.
Absorbance (10%, H2O, 260 nm):≤0.3; conductivity (100 mM, H2O):≤100 µmhos.
Highly purified non-ionic detergent intended for solubilizing membrane-bound proteins in their native state. Aggregation number: 84.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, store in the refrigerator (4°C) under sterile conditions. Aqueous stock solutions are stable for 3 months at 4°C. Solutions are susceptible to hydrolysis (especially in strong acid) and enzymatic degradation.

Other Notes

Hoshino, T., et al. 1992. J. Biol. Chem.267, 21313.
Levy, D., et al. 1992. Biochim. Biophys. Acta1107, 283.
Nunn, R.S., et al. 1992. J. Mol. Biol.228, 1259.
Lorber, B., et al. 1990. Biochim. Biophys. Acta1023, 254.
Jopski, B., et al. 1989. Biochim. Biophys. Acta978, 79.
Camm, E.L., et al. 1981. Plant Physiol.67, 1061.
Gould, R.J., et al. 1981. Biochemistry20, 6776.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

494460-100GM:
494460-25GM:
494460-500GM:
494460-5GM:
494460-250MG:
494460-1GM:
US2494460-1GM:
494460-VGM:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B Lorber et al.
Biochimica et biophysica acta, 1023(2), 254-265 (1990-04-13)
The commercial non-ionic detergent octyl beta-D-glucopyranoside is often contaminated by significant amounts of UV absorbing and/or ionic compounds that can associate with membrane proteins. Such impurities can be monitored by several techniques (i.e., spectrophotometry, size exclusion chromatography, and pH, conductivity
B Jopski et al.
Biochimica et biophysica acta, 978(1), 79-84 (1989-01-16)
Hemoglobin (Hb) was encapsulated in phosphatidylcholine vesicles by removal of the detergent n-octyl beta-D-glucoside (OG) or n-octyltetraoxyethylene (C8E4) out of mixed detergent-lipid micelles in Hb solution. Three types of apparatus were used for dialysis. Dialysis buffer flow rates, the surface
E L Camm et al.
Plant physiology, 67(5), 1061-1063 (1981-05-01)
The use of the non-ionic detergent octyl beta-d-glucoside has allowed the demonstration in spinach of a chlorophyll a+b-protein complex of apparent molecular weight 29 kilodaltons (Camm and Green, 1980, Plant Physiol 66: 428-432). Complexes analogous to this one also can
T Hoshino et al.
The Journal of biological chemistry, 267(30), 21313-21318 (1992-10-25)
The high affinity branched-chain amino acid transport system (LIV-I) in Pseudomonas aeruginosa is composed of five components: BraC, a periplasmic binding protein for branched-chain amino acids; BraD and BraE, integral membrane proteins; BraF and BraG, putative nucleotide-binding proteins. By using
R S Nunn et al.
Journal of molecular biology, 228(4), 1259-1262 (1992-12-20)
The LH1 light harvesting complex has been purified from a mutant of the photosynthetic bacterium Rhodobacter sphaeroides which synthesizes LH1 as the sole pigment protein. Crystallization trials using polyethylene glycol as the precipitant in the presence of the detergent n-octyl
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