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Safety Information

487928

Sigma-Aldrich

Nocodazole

≥99% (HPLC), solid, microtuble inhibitor, Calbiochem

Synonym(s):

Nocodazole, R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate

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About This Item

Empirical Formula (Hill Notation):
C14H11N3O3S
CAS Number:
31430-18-9
Molecular Weight:
301.32
MDL number:
MFCD00005588
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

Nocodazole, Inhibitor of mitosis.

Quality Level

100

description

RTECS - DD6521000

Assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

pale yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

[s]1c(ccc1)C(=O)c2cc3nc([nH]c3cc2)NC(=O)OC

InChI

1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChI key

KYRVNWMVYQXFEU-UHFFFAOYSA-N

General description

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Promotes tubulin depolymerization
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.

Other Notes

Park, H., et al. 2011. Chem. Med. Chem.in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H341,H361d

Hazard Classifications

Muta. 2 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

487928-1.1ML:
487928-MG:
487928-10MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Esra Unsal et al.
Chemical biology & drug design, 88(6), 783-794 (2016-11-05)
Aurora B is a serine/threonine kinase that has a central role in the regulation of mitosis. The observation of Aurora B overexpression in cancer makes it a promising target to develop antitumoral inhibitors. We describe a new potential inhibitor that
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PLoS biology, 19(9), e3001376-e3001376 (2021-09-08)
Mammalian oocyte meiotic divisions are highly asymmetric and produce a large haploid gamete and 2 small polar bodies. This relies on the ability of the cell to break symmetry and position its spindle close to the cortex before anaphase occurs.
Masashi Minamino et al.
Current biology : CB, 28(16), 2665-2672 (2018-08-14)
Sister chromatid cohesion, mediated by cohesin, is required for accurate chromosome segregation [1, 2]. This process requires acetylation of cohesin subunit SMC3 by evolutionarily conserved cohesin acetyltransferases: Eco1 in budding yeast; XEco1 and XEco2 in Xenopus; and ESCO1 and ESCO2 in
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