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Safety Information

441251

Sigma-Aldrich

α2-Macroglobulin, Human Plasma

A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases.

Synonym(s):

α₂M, α₂MG

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77

Quality Level

100

Assay

≥95% (SDS-PAGE)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

aqueous buffer: soluble

shipped in

ambient

storage temp.

−20°C

General description

A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α2M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.

Biochem/physiol Actions

Cell permeable: no
Primary Target
broad range protease
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.

Other Notes

Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.
Lysiak, J.J., et al. 1995. J. Biol. Chem.270, 21919.
Boisset, N., et al. 1992. J. Struct. Biol.108, 221.
Barrett, A.J. 1980. Methods Enzymol.80, 737.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

441251-10RMG:
441251-100MG:
441251-10MG:
441251-0MG:
441251-1RMG:
441251-1MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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