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Safety Information

377980

Sigma-Aldrich

Hispidin

A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC₅₀ = 2 µM).

Synonym(s):

Hispidin, 6-(3,4-Dihydroxystyrl)-4-hydroxy-2-pyrone

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About This Item

Empirical Formula (Hill Notation):
C13H10O5
CAS Number:
555-55-5
Molecular Weight:
246.22
MDL number:
MFCD01866972
UNSPSC Code:
12352200

Quality Level

100

Assay

≥90% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,15-17H/b3-1+

InChI key

QISBNGLMCHHHFG-HNQUOIGGSA-N

General description

A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC50 = 2 µM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro.
A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC50 = 2 µM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKCβ
Product does not compete with ATP.
Reversible: yes
Target IC50: 2 µM against PKCβ

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gonindard, C., et al. 1997. Cell Biol. Toxicol. 13, 141.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

377980-2MG:
377980-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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