376817-M

Hexokinase II Inhibitor II, 3-BP

The Hexokinase II Inhibitor II, 3-BP, also referenced under CAS 1113-59-3, controls the biological activity of Hexokinase II. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(s): Hexokinase II Inhibitor II, 3-BP, 3-BrPA, Bromopyruvate, Bromopyruvatic Acid, 3-Bromo-2-oxopropionic acid
• Empirical Formula (Hill Notation): C₃H₃BrO₃
• CAS Number: 1113-59-3
• Molecular Weight: 166.96
• MDL number: MFCD00002587
• UNSPSC Code: 12352200
• EC Index Number: 214-206-5

Properties

• Quality Level: 100
• Assay: ≥97% (titration)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 100 mg/mL; distilled water: 100 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7)
• InChI key: PRRZDZJYSJLDBS-UHFFFAOYSA-N

Description

General description

A cell-permeable pyruvic acid derivative that acts as an inhibitor against hexokinase II-mediated glycolysis and effectively suppress tumor survival both in cultures in vitro and in mice and rats in vivo.

Warning

Toxicity: Corrosive (L)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bujis, M., et al. 2009. Invest. New Drugs27, 120.
Chen, Z., et al. 2009. Biochim. Biophys. Acta.1787, 553.
Hulleman, E., et al. 2009. Blood.113, 2014;
Mathupala, S.P., et al. 2009. Semin. Cancer Biol.19, 17.
Pereira da Silva, A.P., et al. 2009. Biochem. J.417, 717.
Yun, J., et al. 2009. Science.325, 1555.
Zhang, X., et al. 2009. Anticancer Res.29, 1443.
Kim, J.S., et al. 2008. J. Bioenerg. Biomembr.40, 607.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H314
• Precautionary Statements: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable