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Safety Information

370625

Sigma-Aldrich

Guanabenz Acetate

A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator.

Synonym(s):

Guanabenz Acetate, 1-(2,6-Dichlorobenzylideneamino)guanidine, Acetate, WY-8678

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About This Item

Empirical Formula (Hill Notation):
C8H8Cl2N4 · xC2H4O2
CAS Number:
Molecular Weight:
231.08 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥99% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;

InChI key

MCSPBPXATWBACD-GAYQJXMFSA-N

General description

A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells (EC50 ~ 400 nM in tunicamycin treated HeLa cells) and acts as a proteostatis regulator. Shown to selectively bind PPP1R15A/GADD34 and disrupt the PPP1R15A-PP1c complex; sustain eIF2α phosphorylation and increase chaperone availability by attenuating translation.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Tsaytler, P., et al. 2011. Science332, 91.
Erb, S., et al. 2000. Neuropsychopharmacology23, 138,
Handley, S.L. and Mithani, S., 1984. Naunyn Schmiedebergs Arch. Pharmacol.327, 1.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

370625-100MG:
370625-MG:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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