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368055

Sigma-Aldrich

Granzyme B Inhibitor II

The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Granzyme B Inhibitor II, Caspase-8 Inhibitor I, Ac-IETD-CHO

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About This Item

Empirical Formula (Hill Notation):
C21H34N4O10
CAS Number:
1258003-96-1
Molecular Weight:
502.52
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).
Potent, reversible granzyme B and caspase-8 inhibitor.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: yes
Target Ki: 1 nM against caspase-8

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Ile-Glu-Thr-Asp-CHO

Other Notes

Gao, C.F., et al. 2001. Exp. Cell. Res.265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem.273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

368055-MG:
368055-1MG:
368055-5UNMG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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