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345736

Sigma-Aldrich

Ganglioside GD1a, Disialo, Diammonium Salt, Bovine Brain

Useful as a differentiation marker of tumor cell growth.

Synonym(s):

Ganglioside GD1a, Disialo, Diammonium Salt, Bovine Brain, Cer-Glc-Gal(NeuAc)-GalNAc-Gal-NeuAc ·2NH₄

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About This Item

Empirical Formula (Hill Notation):
C84H146N4O39 · 2NH4
Molecular Weight:
1872.14
UNSPSC Code:
12352211
NACRES:
NA.77

Quality Level

100

Assay

≥98% (TLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

DMSO: soluble
chloroform/methanol (2:1): soluble

shipped in

ambient

storage temp.

−20°C

Related Categories

General description

Disialoganglioside prepared from bovine gray matter. Useful as a differentiation marker of tumor cell growth. Protein kinase C inhibitor. Readily converted to GM1 by bacterial and mammalian sialidases without detergent or bile salts. One mole yields 2 moles of sialic acid by thiobarbituric acid assay. The molecular weight is based on stearoyl-18:0.



Note: This product is not to be used for animal treatment, in vivo research, or in any other contact procedure with livestock.
Useful as a differentiation marker of tumor cell growth. Protein kinase C inhibitor. Readily converted to GM1 by bacterial and mammalian neuraminidases without detergent or bile salts. Note: the moleculare weight is based on on stearoyl-18:0.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Protein kinase C
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Irritant (B)

Preparation Note

For use in aqueous systems, dissolve in a small amount of DMSO and then sonicate in buffer or medium, or dissolve the dried sample directly in aqueous buffers by sonication. Solutions may be filter sterilized.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Longee, D.C., et al. 1991. Acta Neuropathologica82, 45.
Livingston, P.O., et al. 1987. Proc Natl. Acad. Sci. USA84, 2911.
Kundu, S.K., and Scott, D.D. 1982. J. Chromato.232, 19.
Wakomari, S. 1981. Annu. Rev. Biochem.50, 733.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

345736-1MG:
345736-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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