344152

FPT Inhibitor II

The FPT Inhibitor II controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(s): FPT Inhibitor II, (E,E)-2-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, 2Na
• Empirical Formula (Hill Notation): C₁₇H₂₈NO₅P · 2Na
• Molecular Weight: 403.36
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: ≥10 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A cell permeable potent and selective inhibitor of farnesyltransferase (FTase; IC₅₀ = 75 nM). Also inhibits Ras farnesylation in whole cells by ~90% at 25-250 µM. Resistant to cleavage by phosphorylation.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

A highly selective and potent inhibitor of Ras farnesyltransferase (IC₅₀ = 75 nM). Inhibits geranylgeranyltransferase I (IC₅₀ = 24 µM) and II (IC₅₀ = 24 µM) at much higher concentrations. Also inhibits Ras farnesylation in whole cells by ~90% at 10-100 µg/ml (25-250 µM). Resistant to cleavage by phosphorylation.

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 75 nM against Ftase

Warning

Toxicity: Standard Handling (A)

Other Notes

Manne, V., et al. 1995. Drug Development Res.34, 121.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable