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Safety Information

343781-M

Sigma-Aldrich

ω-Conotoxin GVIA, Conus geographus

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses.

Synonym(s):

ω-Conotoxin GVIA, Conus geographus, ω-CgTx GVIA

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About This Item

Empirical Formula (Hill Notation):
C120H182N38O43S6
CAS Number:
106375-28-4
Molecular Weight:
3037.35
MDL number:
MFCD00076620
UNSPSC Code:
12352202
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

water: 250 μg/mL
aqueous buffer: soluble

storage temp.

−20°C

General description

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).

Biochem/physiol Actions

Primary Target
Voltage-activated N-type Ca2+ channels
Target IC50: 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors

Warning

Toxicity: Highly Toxic (H)

Sequence

H-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lalo, U.V., et al. 2001. Brain Res. Bull.54, 507.
Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
Olivera, B.M., et al. 1991. J. Biol. Chem.266, 22067.
Protti, D.A., et al. 1991. Brain Res.557, 336.
Werth, J.L., et al. 1991. Mol. Pharmacol.40, 742.
Koyano, K., et al. 1987. Eur. J. Pharmacol.135, 337.
Abe, T., et al. 1986. Neurosci. Lett.71, 203.

Legal Information

Not available for sale outside of the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

343781-UG:
343781-100UG:
343781-100UG-M:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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