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324896

Sigma-Aldrich

eIF-2α Inhibitor II, Sal003

The eIF-2α Inhibitor II, Sal003, also referenced under CAS 301359-91-1, controls the biological activity of eIF-2α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

eIF-2α Inhibitor II, Sal003, 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide, Sal003

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About This Item

Empirical Formula (Hill Notation):
C18H15Cl4N3OS
CAS Number:
301359-91-1
Molecular Weight:
463.21
MDL number:
MFCD00236878
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 10 mg/mL

shipped in

wet ice

storage temp.

−20°C

General description

A cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo.
A cell-permeable Salubrinal (Cat. No. 324895) analog that is reported to be more potent and soluble than Salubrinal. In addition to being a useful tool in studying elF2α-mediated cellular processes in cultures in vitro, enhanced elF2α phosphorylation by Sal003 treatment in the brain (40 pmol per animal) is shown to impair long-term memory in mice in vivo.

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Raven, J.F., et al. 2008. J. Biol. Chem.283, 3097.
Baltzis, D., et al. 2007. J. Biol. Chem.282, 31675.
Kazemi, S., et al. 2007. Mol. Biol. Cell18, 3635.
Costa-Mattioli, M., et al. 2007. Cell129, 195.
Robert, F., et al. 2006. Mol. Biol. Cell17, 4632.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

324896-1.1ML:
324896-MG:
324896-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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