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Safety Information

324732

Sigma-Aldrich

ErbB2 Inhibitor II

The ErbB2 Inhibitor II, also referenced under CAS 928207-02-7, controls the biological activity of ErbB2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

ErbB2 Inhibitor II, 4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole

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About This Item

Empirical Formula (Hill Notation):
C15H10N4O
CAS Number:
928207-02-7
Molecular Weight:
262.27
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC50 = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC50 of 30.9 µM.

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Cheng, Z. Y., et al. 2007. Bioorg. Med. Chem.15, 1533.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

324732-MG:
324732-5MG:
324732-1.1ML:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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