238470

Cremophor^® EL

• Synonym(s): Castor oil polyoxyethylene ether, Ethoxylated castor oil, PEG-35 castor oil, Polyoxyl 35 castor oil, polyoxyl 35 castor oil
• CAS Number: 61791-12-6
• MDL number: MFCD00130879
• UNSPSC Code: 12162002
• NACRES: NA.21

Properties

• form: liquid
• Quality Level: 100
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: clear pale yellow
• CMC: ~0.02%
• solubility: ethanol: soluble; water: soluble, clear (at higher temperatures the solution will be come turbid)
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)
• InChI key: JMNCUXPHXKHBPY-UHFFFAOYSA-N

Description

General description

1 Set = 5 X 25 GM

A mixture of polyoxyethylated triglycerides, by reacting castor oil with ethylene oxide in a molar ratio of 1 : 35, that acts as a nonionic surfactant and serves as a formulation vehicle (p.o. and i.v. administration) for poorly-water soluble pharmacological agents.

Hydrophilic-lipophilic balance (HLB) ~ 12 - 14.

Application

• Proteomic responses of carotenoid and retinol administration to Mongolian gerbils.: This research examines the proteomic responses in Mongolian gerbils administered with carotenoids and retinol. Cremophor^® EL is utilized as a solubilizing agent for these compounds, highlighting its role in biochemical studies involving lipid-soluble substances (Bohn et al., 2018).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Gelderblom, H., et al. 2001. Eur. J. Cancer37, 1590.

Sparreboom, A., et al. 1996. Cancer Res.56, 2112.
Woodcock, D.M., et al. 1990. Cancer Res.50, 4199.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Cremophor is a registered trademark of BASF SE

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 494.6 °F - Not applicable
• Flash Point(C): 257 °C - Not applicable