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Safety Information

218728

Sigma-Aldrich

Caspase-9 Inhibitor III

The Caspase-9 Inhibitor III, also referenced under CAS 403848-57-7, controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Caspase-9 Inhibitor III, Ac-LEHD-CMK

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About This Item

Empirical Formula (Hill Notation):
C24H35ClN6O9
CAS Number:
403848-57-7
Molecular Weight:
587.02
UNSPSC Code:
12352200
NACRES:
NA.54

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

water: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Reported to reduce myocardial infarct size during reperfusion (~70 nM).
A potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (~70 nM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-9
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against caspase-9

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Leu-Glu-His-Asp-CMK

Other Notes

Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

218728-5UNMG:
218728-1MG:
218728-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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