203996

N-Butyldeoxynojirimycin, Hydrochloride

A non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II.

• Synonym(s): N-Butyldeoxynojirimycin, Hydrochloride, NB-DNJ, HCl, N-Butyl-DNJ, HCl
• Empirical Formula (Hill Notation): C₁₀H₂₁NO₄ · xHCl
• CAS Number: 72599-27-0
• Molecular Weight: 219.28 (free base basis)
• MDL number: MFCD00272581
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
• InChI key: UQRORFVVSGFNRO-UTINFBMNSA-N

Description

General description

A non-hormonal, alkylated imino sugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays broad-spectrum anti-viral effects by inhibiting the processing of viral surface glycoproteins. Shown to reversibly induce infertility in male mammals.

A non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays a broad-spectrum anti-viral activity by aiding the misfolding of glycoproteins. Shown to reversibly induce infertility in male mammals. Does not inhibit cell proliferation.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Ceramide-specific glycosyltransferases

Product does not compete with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Dwek, R.A., et al. 2002. Nat. Rev. Drug Discovery1, 65.
van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA99, 17173.
Platt, F.M., et al. 1997. Science276, 428.
Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA91, 2235.
Platt, F.M., et al. 1994. J. Biol. Chem.269, 8362.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable