200488

Bestatin Hydrochloride

InSolution, ≥98%, a metalloprotease inhibitor

• Synonym(s): InSolutionBestatin, Hydrochloride, [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu, HCl
• Empirical Formula (Hill Notation): C₁₆H₂₄N₂O₄ · xHCl
• Molecular Weight: 308.37 (free base basis)
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O.[xHCl]

Description

General description

A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM. The solid form of this compound (Cat. No. 200484) is also available.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Metalloproteases

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

Supplied as a 50 mM (10 mg/580 µL) solution of Bestatatin, HCl in H₂O.

Reconstitution

Following initial, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Other Notes

Merck Index: 14, 9842.
Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab.79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable