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Key Documents

Safety Information

19-148

Sigma-Aldrich

Bafilomycin A1

Synonym(s):

Bafilomycin A

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About This Item

UNSPSC Code:
12352106
eCl@ss:
32160405
NACRES:
NA.41

description

Bafilomycin A1 is a specific potent inhibitor of vacuolar-type H+-ATPases, and blocks lysosomal cholesterol transport in macrophages.

Quality Level

100

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

storage temp.

−20°C

Application

Bafilomycin A1 has been used:
  • as an autophagy inhibitor to study its effect on traumatic brain injury (TBI)-induced cell death and lesions in mice
  • to treat neurons for pH luorin assays to measure endocytosis during synaptic activity
  • to block autophagy in mouse embryonic fibroblasts

Biochem/physiol Actions

Inhibitor Type: Kinase

Physical form

C35H58O9

Storage and Stability

3 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

19-148:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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