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Safety Information

14-724

Sigma-Aldrich

CLK3 Protein, active, 10 µg

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405

recombinant

expressed in baculovirus infected Sf21 cells

Quality Level

100

description

protein target CLK3

purified by

(Ni2+/NTA-agarose)

technique(s)

activity assay: suitable

UniProt accession no.

P49761

Gene Information

human ... CLK3(1198)

General description

FUNCTION: SwissProt: P49761 # Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.
SIZE: 638 amino acids; 73515 Da
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Acrosome (By similarity).
PTM: Autophosphorylates on all three types of residues (By similarity).
SIMILARITY: SwissProt: P49761 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. & Contains 1 protein kinase domain.

Quality

routinely evaluated by phosphorylation of 500μM PKC Substrate Peptide 2 (Catalog # 12-411)

Physical properties

63kDa

Storage and Stability

6 months at -70°C from date of shipment

Analysis Note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

14-724:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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