14-404-M
ZAP-70 Protein, active, 20 µg
Active, recombinant, human, full length ZAP-70 containing a C-terminal His6 tag, for use in Kinase Assays.
Synonym(s):
70 kDa zeta-chain associated protein, SRK, Syk-related tyrosine kinase
About This Item
biological source
human
Quality Level
recombinant
expressed in Sf21 cells
form
liquid
shelf life
6 mo.
mol wt
Mw 70 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... ZAP70(7535)
General description
Product Source: expressed in Sf21 Recombinant, human, full length ZAP-70 containing a C-terminal His6-tag
Zeta-chain-associated protein kinase 70 (ZAP-70) is a cytoplasmic tyrosine kinase that consists of tandem SH2 (tSH2) domains at the beginning, linked with a long linker region, and a tyrosine kinase domain at the C-terminal end.
Biochem/physiol Actions
Target Sub-Family: TK
Zeta-chain-associated protein kinase 70 (ZAP-70) plays a vital role in the development and function of T cells and natural killer cells. It interacts directly with the activated T-cell receptor and regulates downstream signals. In addition, ZAP-70 also mediates B-cell receptor (BCR) signaling. Mutations in ZAP-70 have been associated with severe combined immunodeficiency (SCID), chronic lymphocytic leukemia (CLL) , and the development of autoreactive T cells that attack the joints.
Quality
Physical form
Storage and Stability
Other Notes
Legal Information
Disclaimer
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
14-404M:
14-404:
Certificates of Analysis (COA)
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