Merck
All Photos(3)

1.00263

SAFC

Formic acid

98-100%, EMPROVE® ESSENTIAL

Synonym(s):
Formic acid, Methanoic acid, Formylic acid
Linear Formula:
HCOOH
CAS Number:
Molecular Weight:
46.03
Beilstein:
1209246
MDL number:
EC Index Number:
200-579-1

vapor density

1.6 (vs air)

Quality Level

vapor pressure

44.8 mmHg ( 20 °C)

product line

EMPROVE® ESSENTIAL

Assay

≥98% (alkalimetric)

form

liquid

autoignition temp.

1004 °F

expl. lim.

12-38 % (v/v)
57 %

concentration

98-100%

technique(s)

API processing | polymorph screening: suitable
API processing | salt formation: suitable

refractive index

n20/D 1.370 (lit.)

pH

2.2 (20 °C, 10 g/L in H2O)

bp

100-101 °C (lit.)
101 °C/1013 hPa

mp

8.2-8.4 °C (lit.)

transition temp

flash point 49.5 °C

density

1.22 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.001%
sulfate (SO42-): ≤0.004%
sulfite (SO32-): ≤0.002%

cation traces

As: ≤0.0003%
Cu: ≤0.002%
Pb: ≤0.001%
Zn: ≤0.002%
heavy metals (as Pb): ≤0.0005%

application(s)

liquid formulation
pharmaceutical

storage temp.

15-25°C

SMILES string

OC=O

InChI

1S/CH2O2/c2-1-3/h1H,(H,2,3)

InChI key

BDAGIHXWWSANSR-UHFFFAOYSA-N

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1 of 4

This Item
11-078011-07901283200
Formic acid 98-100%, EMPROVE® ESSENTIAL

SAFC

1.00263

Formic acid

Formic acid JIS special grade, ≥98.0%

Sigma-Aldrich

11-0780

Formic acid

Formic acid SAJ first grade, 88.0-89.5%

Sigma-Aldrich

11-0790

Formic acid

Formic acid United States Pharmacopeia (USP) Reference Standard

USP

1283200

Formic acid

vapor density

1.6 (vs air)

vapor density

1.6 (vs air)

vapor density

1.6 (vs air)

vapor density

1.6 (vs air)

vapor pressure

44.8 mmHg ( 20 °C)

vapor pressure

44.8 mmHg ( 20 °C)

vapor pressure

44.8 mmHg ( 20 °C)

vapor pressure

44.8 mmHg ( 20 °C)

assay

≥98% (alkalimetric)

assay

≥98.0%

assay

88.0-89.5%

assay

-

form

liquid

form

liquid

form

liquid

form

liquid

concentration

98-100%

concentration

-

concentration

-

concentration

-

refractive index

n20/D 1.370 (lit.)

refractive index

n20/D 1.370 (lit.)

refractive index

n20/D 1.370 (lit.)

refractive index

n20/D 1.370 (lit.)

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Formic acid can be used as acidifying agent and buffer component in a variety of pharmaceutical formulations and processes.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

121.1 °F

Flash Point(C)

49.5 °C


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

FSL

Flammable liquids
Type 2 petroleums
Hazardous rank III
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Material Qualification Dossier

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Quality Management Dossier

Available by subscription or for a fee

Operational Excellence Dossier

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Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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