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Key Documents

Safety Information

07-710

Sigma-Aldrich

Anti-SMC2/hCAP-E Antibody

serum, Upstate®

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

NCBI accession no.

NM_001042550.1
NM_001042551.1
NM_006444.2

UniProt accession no.

O95347

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SMC2(10592)

General description

SMC2 and SMC4 from the active ATPase subunit of Condensin I and Condensin II complexes that regulate chromosome compaction.

Specificity

SMC2/hCAP-E

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids 1184-1197 (C-KSKAKPPKGAHVEV) of human SMC2/hCAP-E (Structural Maintenance of Chromosome 2/ Chromosome-Associated Protein E) with an N-terminal cysteine added for conjugation purposes.

Application

Anti-SMC2/hCAP-E Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SMC2/hCAP-E & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair

Quality

Routinely evaluated by immunoblot.

Target description

137kDa

Physical form

Serum

Storage and Stability

2 years at -20°C

Analysis Note

Control
Positive Antigen Control: Catalog #12-309, Hela cell nuclear extract. Add an equal volume of Laemmli reducing sample buffer to 10 μL of extract and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced extract per lane for minigels.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

07-710:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alexander Schleiffer et al.
Molecular cell, 11(3), 571-575 (2003-04-02)
We describe a superfamily of eukaryotic and prokaryotic proteins (kleisins) that includes ScpA, Scc1, Rec8, and Barren. Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure. Since these are the only domains conserved among
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
Yeoh, Eng-Juh, et al.
Cancer Cell, 1, 133-143 (2002)
Takao Ono et al.
Cell, 115(1), 109-121 (2003-10-09)
The canonical condensin complex (henceforth condensin I) plays an essential role in mitotic chromosome assembly and segregation from yeast to humans. We report here the identification of a second condensin complex (condensin II) from vertebrate cells. Condensins I and II
J A Schmiesing et al.
Molecular and cellular biology, 20(18), 6996-7006 (2000-08-25)
Structural maintenance of chromosomes (SMC) family proteins play critical roles in structural changes of chromosomes. Previously, we identified two human SMC family proteins, hCAP-C and hCAP-E, which form a heterodimeric complex (hCAP-C-hCAP-E) in the cell. Based on the sequence conservation
K Kimura et al.
The Journal of biological chemistry, 276(8), 5417-5420 (2001-01-04)
13S condensin is a five-subunit protein complex that plays a central role in mitotic chromosome condensation. The condensin complex was originally identified and purified from Xenopus egg extracts and shown to have an ATP-dependent positive supercoiling activity in vitro. We
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