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06-900

Sigma-Aldrich

Anti-SynGAP Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
western blot: suitable

NCBI accession no.

NM_006772.1

UniProt accession no.

Q96PV0

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SYNGAP1(8831)

General description

Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.

Specificity

SynGAP

Immunogen

peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1274-1293 of rat SynGAP-a

Application

Anti-SynGAP Antibody detects level of SynGAP & has been published & validated for use in IC & WB.
Immunocytochemistry: 0.1 µg/mL has been reported to immunostain SynGAP in neuron cultures fixed with 4% paraformaldehyde, 4% sucrose and perme-abilized with 0.1% Triton X-100 (2).
Research Category
Neuroscience
Research Sub Category
Synapse & Synaptic Biology

Linkage

Replaces: 04-1071

Physical form

Format: Purified
Protein A purified
Purified in PBS with 0.05% NaN3 and 30% Glycerol

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

06-900:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Characterization of a novel synGAP isoform, synGAP-beta.
Li, W; Okano, A; Tian, QB; Nakayama, K; Furihata, T; Nawa, H; Suzuki, T
The Journal of Biological Chemistry null
Ayse Dosemeci et al.
FEBS letters, 590(17), 2934-2939 (2016-08-02)
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B, also known as AIDA-1) is a major component of the postsynaptic density (PSD) in excitatory neurons where it concentrates at the electron-dense core under basal conditions and moves out during
SynGAP isoforms exert opposing effects on synaptic strength.
McMahon, AC; Barnett, MW; O'Leary, TS; Stoney, PN; Collins, MO; Papadia, S; Choudhary et al.
Nature Communications null
MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus.
Qiu, S; Lu, Z; Levitt, P
The Journal of Neuroscience null
Yuko Tanabe et al.
Nature communications, 8(1), 408-408 (2017-09-03)
Coordinated development of excitatory and inhibitory synapses is essential for higher brain function, and impairment in this development is associated with neuropsychiatric disorders. In contrast to the large body of accumulated evidence regarding excitatory synapse development, little is known about

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