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Safety Information

06-756

Sigma-Aldrich

Anti-Frizzled 5 Antibody

Upstate®, from rabbit

Synonym(s):

Fz5, Fzd5

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human, mouse

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NP_003459

UniProt accession no.

Q13467

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... FZD5(7855)

General description

The Wnt family consists of ligands involved in cell fate determination, organogenesis, and oncogenesis. The Wnt signal is thought to be transduced sequentially via a homolog of the frizzled family of receptors to GSK-3 (disheveled), β- and γ- catenin and finally to members of the Tcf/Lef-1 family of HMG box transcription factors. Frizzled 5 is believed to function as the receptor for the Wnt5a ligand.

Specificity

Frizzled 5 (aka Fz5 or Fzd5)

Immunogen

Epitope: C-Terminus
KLH-conjugated, synthetic peptide derived from amino acids 564-585 of human Frizzled 5 (CTGRTPPGPAATYHKQVSLSHV).

Application

Anti-Frizzled 5 Antibody is an antibody against Frizzled 5 for use in WB.
Research Category
Signaling
Research Sub Category
Developmental Signaling

GPCR, cAMP/cGMP & Calcium Signaling

Quality

Routinely evaluated by immunoblot on lysates from mouse liver, C2C12, Jurkat or HUVEC cells

Target description

Frizzled 5 (62kDa)

Physical form

Format: Purified
Protein A chromatography
Purified antibody in PBS with 0.05% sodium azide and 30% Glycerol

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Analysis Note

Control
Lysates from mouse liver, C2C12, Jurkat, and HUVEC

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

06-756:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.
Michaela Bc Kilander,Jacomijn P Dijksterhuis,Ranjani Sri Ganji,Vitezslav Bryja,Gunnar Schulte
Cellular Signalling null
Wnt-frizzled signaling in the induction and differentiation of the neural crest.
Yanfeng, Wang, et al.
Bioessays, 25, 317-325 (2003)
The Frizzled family: receptors for multiple signal transduction pathways.
Huang, Hui-Chuan and Klein, Peter S
Genome Biology, 5, 234-234 (2004)
Y Wang et al.
The Journal of biological chemistry, 271(8), 4468-4476 (1996-02-23)
In Drosophila melanogaster, the frizzled gene plays an essential role in the development of tissue polarity as assessed by the orientation of cuticular structures. Through a combination of random cDNA sequencing, degenerate polymerase chain reaction amplification, and low stringency hybridization
A Bafico et al.
The Journal of biological chemistry, 274(23), 16180-16187 (1999-05-29)
Frizzled related proteins (FRPs) comprise a family of secreted molecules that contain an N-terminal cysteine-rich domain (CRD) highly similar to the CRDs of the frizzled family of membrane-anchored Wnt receptors. FRPs have been shown to interact with Wnt proteins and
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