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Safety Information

05-857

Sigma-Aldrich

Anti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal

clone 2N8, Upstate®, from rabbit

Synonym(s):

KAT13A

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2N8, monoclonal

species reactivity

vertebrates, mouse

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_005417

UniProt accession no.

P12931

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr416)

Gene Information

human ... SRC(6714)

Specificity

phospho-c-Src (Tyr416)

Immunogen

synthetic peptide containing the sequence ...NE[pY]TA, where pY corresponds to phosphotyrosine at position 416 of c-Src.

Application

Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling
This Anti-phospho-Src family (Tyr416) Antibody, clone 2N8 is validated for use in WB for the detection of phospho-Src family (Tyr416).

Quality

Routinely evaluated by immunoblot of endogenous phospho-c-Src immunoprecipitated from NIH/3T3 RIPA lysates with anti-Src, clone GD11 agarose beads (Cat # 16-186)

Target description

60kDa

Linkage

Replaces: 16-249

Physical form

Format: Purified
Protein A purified

Storage and Stability

2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

05-857:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Molecular interdiction of Src-family kinase signaling in hematopoietic cells.
Geahlen, Robert L, et al.
Oncogene, 23, 8024-8032 (2004)
Structure and regulation of Src family kinases.
Boggon, Titus J and Eck, Michael J
Oncogene, 23, 7918-7927 (2004)
The interplay between Src family kinases and receptor tyrosine kinases.
Bromann, Paul A, et al.
Oncogene, 23, 7957-7968 (2004)
Src protein-tyrosine kinase structure and regulation.
Roskoski, Robert
Biochemical and biophysical research communications, 324, 1155-1164 (2004)
Keiji Tamaoki et al.
Cell & bioscience, 6, 2-2 (2016-01-23)
Amphibians are able to survive for several months without food. However, it is unclear what molecular mechanisms underlie their survival. To characterize the intestinal responses to fasting and refeeding, we investigated morphological, biochemical, transcriptional and epigenetic changes in the intestine

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