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Safety Information

05-832

Sigma-Aldrich

Anti-LKB1 Antibody, clone 5c10

clone 5c10, Upstate®, from mouse

Synonym(s):

Anti-LKB1, Anti-hLKB1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

5c10, monoclonal

species reactivity

mouse, rat, human

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_000455

UniProt accession no.

Q15831

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... STK11(6794)

Specificity

Recognizes LKB1.

Immunogen

GST fusion protein corresponding to residues 1-433 of human LKB1

Application

Research Category
Signaling
Research Sub Category
Insulin/Energy Signaling
This Anti-LKB1 Antibody, clone 5c10 is validated for use in IC, WB for the detection of LKB1.

Quality

routinely evaluated by immunoblot on RIPA lysates from Rat2 cells

Target description

55 kDa

Physical form

Format: Purified
Protein G Purified
Protein G Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% Sodium Azide, pH 7.4.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Rat2 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

05-832:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yuji Nakada et al.
PloS one, 8(9), e73449-e73449 (2013-10-03)
Germline mutations in the LKB1 gene (also known as STK11) cause the Peutz-Jeghers Syndrome, and somatic loss of LKB1 has emerged as causal event in a wide range of human malignancies, including melanoma, lung cancer, and cervical cancer. The LKB1
A F Baas et al.
The EMBO journal, 22(12), 3062-3072 (2003-06-14)
The LKB1 gene encodes a serine/threonine kinase mutated in Peutz-Jeghers cancer syndrome. Despite several proposed models for LKB1 function in development and in tumour suppression, the detailed molecular action of LKB1 remains undefined. Here, we report the identification and characterization
Molecular diagnosis and clinical relevance of t(9;22), t(4;11) and t(1 ;19) chromosome abnormalities in a consecutive group of 141 adult patients with acute lymphoblastic leukemia
Rambaldi, A., et al
Leukemia & Lymphoma, 21, 457-466 (1996)
Samantha M Behunin et al.
Archives of biochemistry and biophysics, 601, 32-41 (2016-03-15)
Contractile perturbations downstream of Ca(2+) binding to troponin C, the so-called sarcomere-controlled mechanisms, represent the earliest indicators of energy remodeling in the diseased heart [1]. Central to cellular energy "sensing" is the adenosine monophosphate-activated kinase (AMPK) pathway, which is known
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
Baas, A. F., et al
Cell, 116, 457-466 (2004)
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