Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

05-647

Sigma-Aldrich

Anti-Tyrosinase Antibody, clone T311

clone T311, Upstate®, from mouse

Synonym(s):

Anti-Anti-ATN, Anti-Anti-CMM8, Anti-Anti-OCA1, Anti-Anti-OCA1A, Anti-Anti-OCAIA, Anti-Anti-SHEP3

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

T311, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NM_000372

UniProt accession no.

P14679

shipped in

dry ice

target post-translational modification

unmodified

Specificity

Tyrosinase

Immunogen

Purified recombinant Tyrosinase corresponding to residues 5-456 of human Tyrosinase

Application

Not recommended for Immunoprecipitation
Research Category
Neuroscience
Research Sub Category
Neurofilament & Neuron Metabolism

Neuronal & Glial Markers
This Anti-Tyrosinase Antibody, clone T311 is validated for use in WB, IH for the detection of Tyrosinase.

Quality

routinely evaluated by immunoblot on RIPA lysates from SK-MEL-19 cells

Target description

70-80kDa

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Chromatography

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

05-647:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Structure-toxicity relationship of phenolic analogs as anti-melanoma agents: an enzyme directed prodrug approach.
Vad NM, Kandala PK, Srivastava SK, Moridani MY
Chemico-Biological Interactions null
Efficacy of acetaminophen in skin B16-F0 melanoma tumor-bearing C57BL/6 mice.
Nikhil M Vad,Shashi K Kudugunti,Daniel Graber,Nathan Bailey,Kalkunte Srivenugopal,Majid Y Moridani
International journal of oncology null
Hee-Sun Lim et al.
Chonnam medical journal, 52(1), 45-52 (2016-02-13)
As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and diverse oxidative stimuli. However, few studies have examined the role
Y T Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(18), 8125-8129 (1995-08-29)
Tyrosinase (EC 1.14.18.1), the key enzyme in melanin synthesis, has been shown to be one of the targets for cytotoxic T-cell recognition in melanoma patients. To develop serological reagents useful for immunophenotyping melanoma for tyrosinase, human tyrosinase cDNA was expressed
Shashi K Kudugunti et al.
Chemico-biological interactions, 188(1), 1-14 (2010-08-06)
In the current work, we investigated the in vitro biochemical mechanism of Caffeic Acid Phenylethyl Ester (CAPE) toxicity and eight hydroxycinnamic/caffeic acid derivatives in vitro, using tyrosinase enzyme as a molecular target in human SK-MEL-28 melanoma cells. Enzymatic reaction models
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service