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Key Documents

Safety Information

05-533

Sigma-Aldrich

Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1

clone 22B1, Upstate®, from mouse

Synonym(s):

Anti-Anti-CAMKA, Anti-Anti-CaMKIINalpha, Anti-Anti-CaMKIIalpha, Anti-Anti-MRD53, Anti-Anti-MRT63

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

22B1, monoclonal

species reactivity

rat

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG1

NCBI accession no.

NM_015981 (and others)

UniProt accession no.

Q9UQM7

shipped in

wet ice

target post-translational modification

phosphorylation (pThr286)

Gene Information

human ... CAMK2A(815)

Specificity

phospho-CaM Kinase II α subunit

Immunogen

Peptide corresponding to residuues 281-294 of rat Cam Kinase II alpha-subunit; recognizes phosphorylated CaM Kinase II on Threonine 286

Application

Detect phospho-CaM Kinase II using this Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1 validated for use in WB.

Quality

routinely evaluated by immunoblot on rat brain microsomal protein preparation

Target description

50kDa

Physical form

Format: Purified

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

05-533:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth.
Kim, JH; Lee, JA; Song, YM; Park, CH; Hwang, SJ; Kim, YS; Kaang, BK; Son, H
Faseb Journal null
Su-Ying Cui et al.
Journal of neurochemistry, 136(3), 609-619 (2015-11-13)
The Ca(2+) modulation in the dorsal raphe nucleus (DRN) plays an important role in sleep-wake regulation. Calmodulin-dependent kinase II (CaMKII) is an important signal-transducing molecule that is activated by Ca(2+) . This study investigated the effects of intracellular Ca(2+) /CaMKII
Comparative biology of cystic fibrosis animal models.
Fisher, JT; Zhang, Y; Engelhardt, JF
Methods in Molecular Biology null
B L Patton et al.
Molecular biology of the cell, 4(2), 159-172 (1993-02-01)
We have visualized the distribution of autophosphorylated type II CaM kinase in neural tissue with the use of two complementary antibodies: a monoclonal antibody that binds to the alpha and beta subunits of the kinase only when they are autophosphorylated
Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring.
Opazo, MC; Gianini, A; Pancetti, F; Azkcona, G; Alarcon, L; Lizana, R; Noches et al.
Endocrinology null
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