M-080

Methylmalonic acid solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₄H₆O₄
• CAS Number: 516-05-2
• Molecular Weight: 118.09
• EC Number: 200-835-2
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in acetonitrile
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing; pharmaceutical (small molecule)
• format: single component solution
• storage temp.: −20°C
• SMILES string: CC(C(O)=O)C(O)=O
• InChI: 1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)
• InChI key: ZIYVHBGGAOATLY-UHFFFAOYSA-N

Description

General description

Methylmalonic acid is an indicator of vitamin B₁₂ deficiency and methylmalonic acidemia. This Certified Spiking Solution^® is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.

Application

• Organic acid analysis for metabolic profiling: Research highlighted the integration of soil microbiota and metabolome, where methylmalonic acid was part of the metabolic profiling, revealing insights into how controlled release fertilizer impacts sugarcane growth, emphasizing the compound′s role in agricultural biotechnology (Yuan et al., 2023).



• Vitamin B12 deficiency research: Methylmalonic acid was featured in research on the cellular mechanisms affecting the MAFB/NOTCH3 axis in osteosarcoma, where its levels could potentially reflect perturbations relevant to vitamin B12 deficiency, aiding in better understanding of disease progression (Zhang et al., 2024).



• Methylmalonic acid standard for mass spectrometry analysis: The analysis of soybean root systems under varying nutrient conditions included methylmalonic acid as a standard in mass spectrometry to better understand nutrient uptake mechanisms, showcasing its utility in plant physiology and biochemistry studies (Qin et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H302 + H312 + H332,H319
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 35.6 °F - closed cup
• Flash Point(C): 2 °C - closed cup