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Safety Information

M-005

Supelco

Morphine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C17H19NO3
CAS Number:
Molecular Weight:
285.34
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

CN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O)c35

InChI

1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1

InChI key

BQJCRHHNABKAKU-KBQPJGBKSA-N

Gene Information

human ... OPRM1(4988)

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General description

This certified analytical reference standard is suitable for a variety of GC/MS or LC/MS applications from pain prescription monitoring, clinical toxicology, and urine drug testing to pharmaceutical research and forensic analysis.

Morphine is a natural phenolic alkaloid, commonly used as an analgesic and anti-inflammatory properties. Sold under trade names including MS Contin®, Kadian®, Oramorph®, and Roxanol, morphine is also a commonly abused recreational drug due to its widespread availability and a high potential for addiction.

Application

The certified reference solution (CRM) in solution can also be used as follows:
  • Development of a hydrogel-modified carbon paste electrode (HCPE) for the electrochemical determination of morphine in very low volume solutions using differential pulse voltammetry
  • Combination of magnetic molecularly imprinted solid phase extraction (MMISPE) with high-performance liquid chromatography (HPLC) to analyze urine samples for quantifying morphine
  • Electrochemical detection and measurement of morphine and 3,4-methylenedioxymethamphetamine (MDMA) in human urine and serum samples using carbon nanohorns modified with Pt nanoparticles (CNHs@PtNPs) based sensor
  • Simultaneous determination of morphine and naltrexone in bulk and their combined solid dosage formulations using a stability-indicating high-performance liquid chromatographic method combined with a photodiode array detector
  • Colorimetric estimation of morphine and ibuprofen in human serum and urine samples as per the difference in the aggregation of citrate-capped gold nanoparticles (AuNPs) analyzed by infra-red (IR) spectroscopy and transmission electron microscopy (TEM)

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Kadian is a registered trademark of Actavis Elizabeth LLC
MS Contin is a registered trademark of Purdue Frederick Company
Oramorph is a registered trademark of AAIPharma, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Alcohols
Hazardous rank II

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

M-005-1ML:
M-005-CC:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mean versus median in tables and figures.
Tim Thomas Joseph et al.
Anesthesia and analgesia, 116(6), 1390-1391 (2013-05-28)
In response.
Alain Gorgeat
Anesthesia and analgesia, 116(6), 1391-1391 (2013-07-12)
Importance of reducing pain during routine procedures.
Michael C Petty
Journal of the American Veterinary Medical Association, 242(8), 1048-1048 (2013-05-15)
Thitima Chinachoti et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(5), 589-594 (2013-06-12)
Presently, in Siriraj Hospital, intrathecal morphine is routinely used in spinal anesthesia for postoperative pain control in more than 600 cases per month with doses lower than 0.3 mg. However, the incidence of side effects is high. This retrospective data
A Bilir
Clinical and experimental obstetrics & gynecology, 40(1), 118-121 (2013-06-04)
Pain management has a particular importance after Cesarean section. This study was undertaken in order to document the efficacy and side-effects of epidural morphine instead of patient-controlled analgesia technique used for the control of post-cesarean pain during postoperative 24-48 hours.

Articles

Although both biphenyl and phenyl-hexyl phases can resolve these compounds, the former exhibits excellent peak shape and substantially less silanol-derived ion exchange activity.

Protocols

To optimize hydrolysis using β-glucuronidase, factors such as incubation time, temperature, hydrolysis pH, enzyme source, and enzyme concentration must be evaluated for each glucuronide metabolite to be analyzed.

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