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Safety Information

H-003

Supelco

Hydrocodone solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C18H21NO3
CAS Number:
125-29-1
Molecular Weight:
299.36
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

InChI

1S/C18H21NO3.C4H6O6.H2O/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;5-1(3(7)8)2(6)4(9)10;/h3,6,11-12,17H,4-5,7-9H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10);1H2/t11-,12+,17-,18-;1-,2-;/m01./s1

InChI key

ZICRJLQTAUVSDU-NSJZFRMTSA-N

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General description

Hydrocodone is a semi-synthetic opioid derived from codeine or thebaine, two naturally-occurring opiates. The drug, also known as dihydrocodeinone, is used as an analgesic to treat pain and as an antitussive for coughing or related conditions. This Certified Spiking Solution® is suitable as a starting material for calibrators or controls in GC/MS or LC/MS testing applications from pharmaceutical research and pain prescription monitoring to clinical toxicology and forensic analysis.

Application


  • Hydrocodone Bitartrate ER: A Review in Chronic Pain.: This comprehensive review evaluates the extended-release formulation of hydrocodone, focusing on its pharmacological properties, therapeutic efficacy, and clinical applications in managing chronic pain, which underscores its significance in long-term pain management strategies (Dhillon S, 2016).

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

H-005

Hydrocodone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

O-020

Opiate Multi-component Mixture-5 solution, 250 μg/mL each component in methanol, ampule of 1.0 mL, certified reference material, Cerilliant®

H-008

Hydrocodone-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-047

Hydrocodone-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-048

Hydrocodone-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

N-053

Norhydrocodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

N-054

Norhydrocodone-d3 hydrochloride, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

H-003S

Hydrocodone solution, 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Alcohols
Hazardous rank II

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

H-003-1ML:
H-003-CC:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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FDA committee: More restrictions needed on hydrocodone combination products.
Bridget M Kuehn
JAMA, 309(9), 862-862 (2013-03-07)
Rachel Wightman et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 8(4), 335-340 (2012-09-21)
Nonmedical use of prescription opioid analgesics is associated with epidemic levels of morbidity and mortality. There are several factors that affect the abuse liability of the various opioids, including likability or the pleasurable subjective effects. Due to rising public health
David Alexander et al.
The Laryngoscope, 122(11), 2378-2381 (2012-09-12)
Two million new users will abuse prescription narcotics this year, most commonly hydrocodone. The most commonly prescribed form is hydrocodone-acetaminophen (HA). Many individuals crush the tablets and snort the product to take advantage of the rapid transmucosal delivery of narcotics.
Justin D Khetani et al.
Paediatric drugs, 14(6), 411-415 (2012-09-28)
Recent case reports have alerted the medical community of fatality in children receiving codeine after tonsillectomy and/or adenoidectomy for obstructive sleep apnea syndrome. The objective of this study was to compare the rates of oxygen desaturation before and after adenotonsillectomy
Recent issues regarding controlled substances.
Dave Helgeland
South Dakota medicine : the journal of the South Dakota State Medical Association, 66(3), 105-105 (2013-04-03)
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Articles

Benefits of Ascentis Express Phenyl-Hexyl over Biphenyl for the Separation of Pain Management Opiates

Although both biphenyl and phenyl-hexyl phases can resolve these compounds, the former exhibits excellent peak shape and substantially less silanol-derived ion exchange activity.

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