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890850O

Avanti

18:1 DAP

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dioleoyl-3-dimethylammonium-propane (DODAP)

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About This Item

Empirical Formula (Hill Notation):
C41H77NO4
CAS Number:
127512-29-2
Molecular Weight:
648.05
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 2 × 100 mg (890850O-200mg)
pkg of 1 × 25 mg (890850O-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(CN(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O

General description

18:1 DAP is a cationic lipid, used for the preparation of cationic liposomes.

Application

18:1 DAP is suitable for:
  • as a component of lipid bilayers
  • in the formulation of stable nucleic acid lipid vesicles
  • in the preparation and physicochemical characterization of antisense oligodeoxyribonucleotide (ODN)-containing folate (FA)-targeted or non-targeted liposomes

Packaging

5 mL Clear Glass Sealed Ampule (890850O-200mg)
5 mL Clear Glass Sealed Ampule (890850O-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

890850O-200MG:
890850O-VAR:
890850O-25MG:
890850O-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Preparation and in-vitro evaluation of an antisense-containing cationic liposome against non-small cell lung cancer: a comparative preparation study
Saffari M, et al.
Iranian Journal of Pharmaceutical Research : IJPR, 12(Suppl), 3-3 (2013)
Transferrin-conjugated SNALPs encapsulating 2?-O-methylated miR-34a for the treatment of multiple myeloma
Scognamiglio I, et al.
BioMed Research International, 2014 (2014)
Nonequilibrium adhesion patterns at lipid bilayer junctions
Parthasarathy R, et al.
The Journal of Physical Chemistry B, 108(2), 649-657 (2004)
Qiang Cheng et al.
Nature nanotechnology, 15(4), 313-320 (2020-04-07)
CRISPR-Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that selectively target specific tissues. Here, we report a strategy

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