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890703P

Avanti

18:0 EPC (Cl Salt)

Avanti Research™ - A Croda Brand 890703P, powder

Synonym(s):

1,2-distearoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

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About This Item

Empirical Formula (Hill Notation):
C46H93NO8PCl
CAS Number:
328268-13-9
Molecular Weight:
854.66
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 25 mg (890703P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 890703P

lipid type

transfection
cationic lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)OCC.[Cl-]

Application

1,2-distearoyl-sn-glycero-3-ethylphosphocholine (18:0 EPC) might be used:
  • to study its effect on the synergistic antimicrobial action of eugenol against Escherichia coli C600
  • to test its use in the formation of lipid nanoparticle variants
  • as a constituent of the microbubble formulation
  • to prepare lipid monolayer for the study on the nature and orientation of interaction between graphene oxide (GO) and lipid models

Biochem/physiol Actions

Cationic lipids are useful co-adjuvants for promoting the immunogenicity of vaccines. 1,2-distearoyl-sn-glycero-3-ethylphosphocholine (18:0 EPC) is a cationic lipid and is found to upregulate cluster of differentiation (CD)80 and CD86 co-stimulatory molecules. The hydrophilic moiety and the acyl chains of the cationic lipids highly influences their co-stimulatory action.

Packaging

5 mL Amber Glass Screw Cap Vial (890703P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

890703P-BULK:
890703P-25MG:
890703P-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jurriaan J J Gillissen et al.
Langmuir : the ACS journal of surfaces and colloids, 34(1), 503-511 (2017-12-05)
Enclosed lipid bilayer structures, referred to as liposomes or lipid vesicles, have a wide range of biological functions, such as cellular signaling and membrane trafficking. The efficiency of cellular uptake of liposomes, a key step in many of these functions
Caroline Lonez et al.
Advanced drug delivery reviews, 64(15), 1749-1758 (2012-05-29)
Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges close to cell surface is likely to be recognized as a
Boris G Tenchov et al.
Biochimica et biophysica acta, 1778(10), 2405-2412 (2008-08-30)
Synthetic cationic lipids can be used as DNA carriers and are regarded to be the most promising non-viral gene carriers. For this investigation, six novel phosphatidylcholine (PC) cationic derivatives with various hydrophobic moieties were synthesized and their transfection efficiencies for
Rumiana Koynova et al.
Biochimica et biophysica acta, 1768(2), 375-386 (2006-12-13)
Lipoplexes containing a mixture of cationic phospholipids dioleoylethylphosphatidylcholine (EDOPC) and dilauroylethylphosphatidylcholine (EDLPC) are known to be far more efficient agents in transfection of cultured primary endothelial cells than are lipoplexes containing either lipid alone. The large magnitude of the synergy
Li Wang et al.
Molecular pharmaceutics, 4(4), 615-623 (2007-04-06)
To date, the primary approach to improving the transfection properties of cationic lipids has been the synthesis of new kinds of cationic amphipaths. Recently, however, it was found that combining two cationic lipid derivatives having the same head group but
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