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Safety Information

810262P

Avanti

C11 TopFluor™ Ceramide

N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine, powder

Synonym(s):

N-[11-(TopFluor)undecanoyl]-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):
C42H70N3O3F2
CAS Number:
1246355-58-7
Molecular Weight:
703.02
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 250 μg (810262P-250ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810262P

shipped in

dry ice

storage temp.

−20°C

General description

Ceramide, a bioactive sphingolipid belongs to the sphingolipid family of cell lipids. This pore-forming member is insoluble in water. It is a hygroscopic and light sensitive lipid.

Application

C11 TopFluor™ Ceramide may be used:
  • in the ceramide and B-cell lymphoma-extra-large (Bcl-xL) binding studies to study the effect on ceramide channel formation
  • as a tracer in confocal microscopy to treat T84 cells in order to study its localization in sphingomyelinase (SMase)-induced F-actin structures
  • to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy

Biochem/physiol Actions

Ceramide is known to participate in apoptosis, mediated by mitochondria. Ceramide channels plays a key role in the onset of apoptosis in vivo.

Packaging

5 mL Amber Glass Screw Cap Vial (810262P-250ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

810262P-250UG:
810262P-VAR:
810262P-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion
Saslowsky DE, et al.
Molecular Biology of the Cell, 27(7), 1120-1130 (2016)
Ceramide Channels: Destabilization by Bcl-xL and Role in Apoptosis
Chang KT, et al.
Biochimica et Biophysica Acta, 1848(10 0 0), 2374-2374 (2015)
Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide-1-phosphate promote pancreatic cancer stem cell motility
Kuc N, et al.
Biochemical Pharmacology, 156, 458-466 (2018)

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