700121P

sitostanol

β-sitostanol, powder

• Synonym(s): stigmastanol; dihydrositosterol; (3β)-stigmastan-3-ol; (3β,5α)-stigmastan-3-ol
• Empirical Formula (Hill Notation): C₂₉H₅₂O
• CAS Number: 83-45-4
• Molecular Weight: 416.72
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 5 mg (700121P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 700121P
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C29H52O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h19-27,30H,7-18H2,1-6H3/t20-,21-,22+,23+,24+,25-,26+,27+,28+,29-/m1/s1
• InChI key: LGJMUZUPVCAVPU-HRJGVYIJSA-N

Description

General description

It is predominantly present in pine oil.

Sitostanol is a 5α-saturated sitosterol derivative.

Sitostanol is a plant stanol and a hydrogenated form of sitosterol.

Application

Sitostanol is suitable for its use as a component in micelle preparation, used for cell culture and cellular uptake studies. It is also suitable for use in cell culture to study its effect on a T-helper-1 shift in peripheral blood mononuclear cells (PBMCs) from asthma patients.

Sitostanol may be used in the preparation of binary phospholipid for thermodynamic studies and Brewster angle microscopy studies. It may also be used as a standard steroid in gas chromatography-mass spectrometry(GC-MS).

Biochem/physiol Actions

Plant stanols are structurally similar to cholesterol, hence it reduces the plasma level of LDL cholesterol. Sitostanol is known to possess hypolipidemic and antiatherogenic effects.

Sitostanol decreases cholesterol absorption. Its ratio with cholesterol is implicated in non-alcoholic fatty liver disease (NAFLD). The ratio also correlates with liver steatosis and inflammation. Sitostanol induces interferon γ production and T-helper response in peripheral blood mononuclear cells (PBMC) in asthma patients. It is a hypocholestremic agent as it decreases the micellar solubility and absorption of cholesterol.

Sitostanol lowers the intestinal absorption of cholesterol and serum cholesterol.

Packaging

5 mL Amber Glass Screw Cap Vial (700121P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids