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700044P

Avanti

7β-hydroxycholesterol-d7

Avanti Research™ - A Croda Brand

Synonym(s):

cholest-5-ene-3b,7b-diol(d7)

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About This Item

Empirical Formula (Hill Notation):
C27H39O2D7
CAS Number:
349553-97-5
Molecular Weight:
409.70
UNSPSC Code:
12352100
NACRES:
NA.25

description

cholest-5-en-3β,7β-diol-d7

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700044P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

General description

7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol. 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.

Application

7β-hydroxycholesterol-d7 has been used:
  • as cholesterol oxidation product for mass spectroscopy analysis
  • as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis
  • as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry
  • as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification

Biochem/physiol Actions

7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.

Packaging

5 mL Amber Glass Screw Cap Vial (700044P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

700044P-1MG:
700044P-VAR:
700044P-BULK:

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Virginie Aires et al.
Scientific reports, 9(1), 9134-9134 (2019-06-27)
Obesity may not be consistently associated with metabolic disorders and mortality later in life, prompting exploration of the challenging concept of healthy obesity. Here, the consumption of a high-fat/high-sucrose (HF/HS) diet produces hyperglycaemia and hypercholesterolaemia, increases oxidative stress, increases endotoxaemia
Guilherme Silva Ferreira et al.
Frontiers in physiology, 8, 644-644 (2017-09-21)
Background: Oxysterols are bioactive lipids that control cellular cholesterol synthesis, uptake, and exportation besides mediating inflammation and cytotoxicity that modulate the development of atherosclerosis. Aerobic exercise training (AET) prevents and regresses atherosclerosis by the improvement of lipid metabolism, reverse cholesterol
Louise Ménégaut et al.
Cell reports, 31(7), 107665-107665 (2020-05-21)
Low-grade inflammation is constitutive of atherosclerosis, and anti-inflammatory therapy inhibiting interleukin-1β (IL-1β) reduces the rate of cardiovascular events. While cholesterol accumulation in atheroma plaque and macrophages is a major driver of the inflammatory process, the role of the LXR cholesterol

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