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Safety Information

W239607

Sigma-Aldrich

Dimethyl succinate

98%, FG

Synonym(s):

Dimethyl butanedioate, Succinic acid dimethyl ester

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About This Item

Linear Formula:
CH3OCOCH2CH2COOCH3
CAS Number:
106-65-0
Molecular Weight:
146.14
FEMA Number:
2396
Beilstein:
956776
EC Number:
203-419-9
Council of Europe no.:
439
MDL number:
MFCD00008466
UNSPSC Code:
12164502
PubChem Substance ID:
24901044
Flavis number:
9.445
NACRES:
NA.21
grade:
FG
Halal
Kosher
biological source:
synthetic
food allergen:
no known allergens

biological source

synthetic

Quality Level

400

grade

FG
Halal
Kosher

reg. compliance

EU Regulation 1334/2008 & 178/2002
FDA 21 CFR 117
FDA 21 CFR 172.515

vapor pressure

0.3 mmHg ( 20 °C)

Assay

98%

autoignition temp.

689 °F

expl. lim.

8.5 %

refractive index

n20/D 1.419 (lit.)

bp

200 °C (lit.)

mp

16-19 °C (lit.)

density

1.117 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

Organoleptic

green; fruity; floral; sweet

SMILES string

COC(=O)CCC(=O)OC

InChI

1S/C6H10O4/c1-9-5(7)3-4-6(8)10-2/h3-4H2,1-2H3

InChI key

MUXOBHXGJLMRAB-UHFFFAOYSA-N

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Related Categories

General description

Dimethyl succinate can be used as a flavoring agent in the food industry.

Application


  • Metabolic Bypass Rescues Aberrant S-nitrosylation-Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer′s Disease Human Neurons.: This research discusses the role of metabolic intermediates like Dimethyl succinate in bypassing biochemical blocks in Alzheimer′s disease, offering potential therapeutic avenues (Andreyev et al., 2024).

  • Update to RIFM fragrance ingredient safety assessment, dimethyl succinate, CAS Registry Number 106-65-0.: A comprehensive safety assessment of Dimethyl succinate as a fragrance ingredient, highlighting its toxicological profile and safe usage parameters (Api et al., 2023).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

201.2 °F - closed cup

Flash Point(C)

94 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

W239607-SAMPLE:
W239607-BULK-K:
W239607-10KG-K:4548173968773
W239607-25KG:
W239607-25KG-K:4548173968797
W239607-10KG:
W239607-SAMPLE-K:
W239607-1KG-K:4548173968780
W239607-1KG:
W239607-VAR-K:

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Certificates of Analysis (COA)

Lot/Batch Number
SHBN8044
SHBN8042
SHBN4003
SHBM4198
SHBL6508

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Dimethyl methylsuccinate 98%

Sigma-Aldrich

178799

Dimethyl methylsuccinate

Diethyl succinate natural, ≥99%, FG

Sigma-Aldrich

W237712

Diethyl succinate

Burdock, GA
Encyclopedia of Food and Color Additives, 1, 878-879 (1997)
L Ladriere et al.
JPEN. Journal of parenteral and enteral nutrition, 20(4), 251-256 (1996-07-01)
Succinic acid dimethyl ester (SAD) is efficiently metabolized in several cell types as pancreatic islet cells, hepatocytes, and colonocytes. The purpose of this study was to assess the overall nutritional value of SAD in the whole organism. SAD was infused
André Mukala-Nsengu et al.
Biochemical pharmacology, 67(5), 981-988 (2004-04-24)
The relative contribution of glycolysis vs. oxidative metabolism to the stimulus secretion coupling mechanism of beta-cells was investigated in isolated islets. For that purpose, the secretory and intracellular calcium responses of islets to both glucose and succinic acid dimethyl ester
Lili Yang et al.
The Journal of biological chemistry, 283(32), 21978-21987 (2008-06-12)
We conducted a study coupling metabolomics and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle. Rat livers were perfused with lactate or pyruvate +/- aminooxyacetate or mercaptopicolinate in the presence of 40% enriched NaH(13)CO(3). Other livers were perfused
J Cancelas et al.
International journal of molecular medicine, 8(3), 269-271 (2001-08-09)
It was recently proposed that suitable succinic acid esters could be used to potentiate the insulinotropic action of glucagon-like peptide 1 (GLP-1) in the treatment of type-2 diabetes mellitus. In such a perspective, the present study aimed mainly at investigating
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Global Trade Item Number

SKUGTIN
W239607-1KG
W239607-SAMPLE-K4061837519901
W239607-10KG-K4061837519871
W239607-10KG
W239607-1KG-K4061837519888
W239607-25KG
W239607-25KG-K4061837519895
W239607-SAMPLE

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