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Safety Information

QBD11451

Sigma-Aldrich

MAL-dPEG®12-Tris(-dPEG®24-acid)3

>90% (HPLC)

Synonym(s):

Branched Maleimide-PEG-acid, Branched carboxy-PEG-maleimide, MAL-PEG12-Tris(-PEG24-acid)3, MAL-PEG600-Tris(PEG1200-COOH)3

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About This Item

Empirical Formula (Hill Notation):
C200H384N6O100
Molecular Weight:
4473.17
UNSPSC Code:
12352106
NACRES:
NA.22

Assay

>90% (HPLC)

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

polymer architecture

functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)NC(COCCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)(COCCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)COCC

Features and Benefits

MAL-dPEG12-Tris(-dPEG24-acid)3 is a thiol- and amine-reactive, four-arm, monodispersed PEG with one arm shorter than the other three. This product is useful for charge modulation and elimination of renal clearance in drug delivery and imaging applications, among others. The dPEG spacer length from the maleimide olefin to the carbonyl carbon on each of the three long arms is 129 atoms. The average distance from maleimide to carbonyl carbon is 80.4 Å.

Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

QBD11451-25MG:

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Haiming Ding et al.
Bioconjugate chemistry, 24(11), 1945-1954 (2013-11-02)
The tumor-associated glycoprotein-72 (TAG-72) antigen is highly overexpressed in various human adenocarcinomas and anti-TAG-72 monoclonal antibodies, and fragments are therefore useful as pharmaceutical targeting vectors. In this study, we investigated the effects of site-specific PEGylation with MW 2-4 kDa discrete

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