QAMINESET

QuicTPD Amine Screening Set

Properties

• storage temp.: 2-8°C
• Quality Level: 100

Description

General description

QTPD Amine set comprised of 36 partial protacs plated in duplicate with rich linker diversity, architecture and length targeting Cereblon(CRBN) and von Hippel Lindau( VHL) E3 ligases ending in a amine terminal.

Application

This set can be used for reacting with warheads/ligands for targets of interest with solvent exposed pendant carboxylic acid handles via peptide coupling reactions. Two distinct warheads can be reacted with this set to generate 72 distinct small molecule degraders that can be used for subsequent screening.

Features and Benefits

Representative set of partial protacs targeting both CRBN and VHL with typical PEG, hydrophobic and rigid linkers that can be used for construction of PROTACs. Customers can make screen upto 24 reaction conditions with this set and empty glass shell vials provided with the pre-plated set. Glass shell vials allow for exploration of reaction conditions tolerant to different, reagents, solvents and temperature. Miniaturized synthesis allows for reduction in solvent, reagent, water and energy usage making this a sustainable and faster route to PROTAC discovery.

Other Notes

QuicTPD Amine Screening Set

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H361d,H373
• Precautionary Statements: P202 - P260 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2
• Target Organs: Blood
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3