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Safety Information

P22370

Sigma-Aldrich

trans-2-Phenylcyclopropylamine hydrochloride

97%

Synonym(s):

Tranylcypromine

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About This Item

Linear Formula:
C6H5C3H4NH2·HCl
CAS Number:
1986-47-6
Molecular Weight:
169.65
MDL number:
MFCD00063602
UNSPSC Code:
12352100
PubChem Substance ID:
24898296
NACRES:
NA.22

Assay

97%

form

solid

optical activity

[α]/D −1 to +1.0°, c = 1 in H2O

mp

162-169 °C (lit.)

storage temp.

2-8°C

SMILES string

Cl.N[C@@H]1C[C@H]1c2ccccc2

InChI

1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1

InChI key

ZPEFMSTTZXJOTM-OULXEKPRSA-N

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Related Categories

Biochem/physiol Actions

Non-selective MAO-A/B inhibitor.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P22370-10G:
P22370-BULK:
P22370-VAR:
P22370-1G:
P22370-2.5G:

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Certificates of Analysis (COA)

Lot/Batch Number
BGBC2936V
BGBC2935V
BGBC2546V
BGBB8832
BGBB6650

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Kaisa A Salminen et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(12), 1891-1904 (2015-09-25)
The cytochrome P450 2C19 (CYP2C19) enzyme plays an important role in the metabolism of many commonly used drugs. Relatively little is known about CYP2C19 inhibitors, including compounds of natural origin, which could inhibit CYP2C19, potentially causing clinically relevant metabolism-based drug
James M Hill et al.
Science translational medicine, 6(265), 265ra169-265ra169 (2014-12-05)
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Ramakrishna Nirogi et al.
Chemico-biological interactions, 230, 9-20 (2015-02-07)
The objective of the study was to evaluate the metabolism dependent inhibition of CYP2B6 catalyzed bupropion hydroxylation in human liver microsomes by monoamine oxidase (MAO) inhibitors and to predict the drug-drug interaction potential of monoamine oxidase inhibitors as perpetrators of
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European journal of pediatrics, 174(4), 509-518 (2014-09-25)
This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated
Christine R Klaus et al.
The Journal of pharmacology and experimental therapeutics, 350(3), 646-656 (2014-07-06)
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