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D167800

Sigma-Aldrich

2,3-Dimethylmaleic anhydride

98%

Synonym(s):

Dimethylmaleic anhydride

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About This Item

Empirical Formula (Hill Notation):
C6H6O3
CAS Number:
766-39-2
Molecular Weight:
126.11
Beilstein:
112044
EC Number:
212-165-8
MDL number:
MFCD00005523
UNSPSC Code:
12162002
PubChem Substance ID:
24893512
NACRES:
NA.23

Assay

98%

form

flakes

bp

223 °C (lit.)

mp

93-96 °C (lit.)

SMILES string

CC1=C(C)C(=O)OC1=O

InChI

1S/C6H6O3/c1-3-4(2)6(8)9-5(3)7/h1-2H3

InChI key

MFGALGYVFGDXIX-UHFFFAOYSA-N

Application

Reagent used in the synthesis of maleimides and as an amino group protecting agent for superoxide dismutase.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

D167800-BULK:
D167800-VAR:
D167800-100G:
D167800-25G:
D167800-5G:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN9693
MKCH6499
MKBR2339V
MKAA2738V
MKBD0422V

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A tumor-acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and drug delivery.
Jin-Zhi Du et al.
Angewandte Chemie (International ed. in English), 49(21), 3621-3626 (2010-04-15)
E Hadas et al.
Journal of chromatography, 510, 303-309 (1990-06-27)
The effect of reversible protection of the free amino groups of poly- and monoclonal antibodies by dimethylmaleic anhydride on their binding activity following immobilization onto various carriers was studied. The treatment with dimethylmaleic anhydride resulted in a 1.6-1.8-fold increase in
Hyeong Sup Yu et al.
Pharmaceutics, 11(6) (2019-06-05)
As caterpillars detect the presence of predators and secrete poison, herein, we show an innovative and highly effective cancer therapeutic system using biocompatible chitosan nanofiber (CNf) installed with a pH-responsive motif that senses tumor extracellular pH, pHe, prior to delivering
M Gerl et al.
Biochemistry, 27(11), 4089-4096 (1988-05-31)
Apoferritin from horse spleen is composed of 24 subunits that undergo partial dissociation after chemical modification with 2,3-dimethylmaleic anhydride (DMMA), yielding dimeric, trimeric, and tetrameric intermediates, stable at pH 8.5 and 0 degrees C. Deacylation at neutral pH and elevated
Bo Reum Lee et al.
International journal of pharmaceutics, 392(1-2), 78-82 (2010-03-20)
A novel synthetic nanocomplex was constructed from glycol chitosan (GCS) grafted with 2,3-dimethylmaleic anhydride (DMA) (denoted as 'GCD' hereafter) and lysozyme (isoelectric point=10.9) as a model protein. This is a core-shell supramolecular assemble formed through electrostatic interactions between anionic GCD
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