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Safety Information

C55402

Sigma-Aldrich

4-Chloro-3-methylphenol

99%

Synonym(s):

4-Chloro-m-cresol, PCMC

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About This Item

Linear Formula:
ClC6H3(CH3)OH
CAS Number:
59-50-7
Molecular Weight:
142.58
Beilstein:
1237629
EC Number:
200-431-6
MDL number:
MFCD00002323
UNSPSC Code:
12352100
PubChem Substance ID:
24892794
NACRES:
NA.22

Quality Level

100

Assay

99%

form

solid

bp

235 °C (lit.)

mp

63-65 °C (lit.)

SMILES string

Cc1cc(O)ccc1Cl

InChI

1S/C7H7ClO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H3

InChI key

CFKMVGJGLGKFKI-UHFFFAOYSA-N

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General description

4-Chloro-3-methylphenol, also known as p-chlorocresol or chloroxylenol, is commonly used as a building block in the synthesis of organic compounds. It can be utilized to synthesize various biologically active compounds, including pharmaceuticals and agrochemicals. (2) Additionally, it serves as a potent disinfectant and antiseptic and is also used as a preservative in medicinal products.

Application

  • Compression of mono-4 chloro, 3-methylphenyl phosphate ester and di-4 chloro, 3-methylphenyl phosphate ester through kinetic study: This study discusses a method using 4-chloro-3-methylphenol and POCl3 taken in a 2:1 ratio, exploring their kinetic behaviors (AR Teli, AA Khan, SH Dar, A Rashid, 2017).
  • Commercially Important Chlorinated Phenols: Reviews the usage of 4-chloro-3-methylphenol among other chlorinated phenols in various industrial applications (K Smith, G El-Hiti).

Signal Word

Danger

Hazard Statements

H302,H314,H317,H335,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1C - Skin Sens. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

244.4 °F - closed cup

Flash Point(C)

118.0 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

C55402-100G:
C55402-BULK:
C55402-250G:
C55402-10KG:
C55402-25KG:
C55402-5G:
C55402-500G:
C55402-VAR:
C55402-1KG:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF9933
BCCD4461
BCCC3096
BCCB3243
BCBZ5305

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Andrew P Ziman et al.
Biophysical journal, 99(8), 2705-2714 (2010-10-21)
Skeletal muscle stores Ca²(+) in the sarcoplasmic reticulum (SR) and releases it to initiate contraction, but the concentration of luminal Ca²(+) in the SR ([Ca²(+)](SR)) and the amount that is released by physiological or pharmacological stimulation has been difficult to
Ian McLaren et al.
Avian pathology : journal of the W.V.P.A, 40(1), 33-42 (2011-02-19)
Two experimental models of Salmonella contamination were used in an attempt to mimic the conditions of disinfectant use on farms. A wet model, for conditions such as boot dips, used disinfectant application to a slurry of poultry faeces inoculated with
Niels Ørtenblad et al.
The Journal of physiology, 589(Pt 3), 711-725 (2010-12-08)
Glucose is stored as glycogen in skeletal muscle. The importance of glycogen as a fuel during exercise has been recognized since the 1960s; however, little is known about the precise mechanism that relates skeletal muscle glycogen to muscle fatigue. We
C D Sanmartin et al.
Neuro-degenerative diseases, 10(1-4), 34-37 (2012-01-31)
Soluble amyloid-β peptide oligomers (AβOs), which are centrally involved in the pathogenesis of Alzheimer's disease, trigger Ca(2+) influx through N-methyl-D-aspartate receptors and stimulate reactive oxygen species generation in primary hippocampal neurons. We have previously reported that AβOs promote Ca(2+) release
Ramón Jiménez-Moreno et al.
Pflugers Archiv : European journal of physiology, 459(5), 725-735 (2010-01-14)
The endoplasmic/sarcoplasmic reticulum (ER/SR) plays a crucial role in cytoplasmic signalling in a variety of cells. It is particularly relevant to skeletal muscle fibres, where this organelle constitutes the main Ca2+ store for essential functions, such as contraction. In this
View All Related Papers

Articles

US EPA Method 8041: GC Analysis of Phenols on Equity®-5

Separation of 2-Chlorophenol; 2,4-Dichlorophenol; 2,4,6-Tribromophenol; 2,4,6-Trichlorophenol; 2,4-Dinitrophenol; Pentafluorophenol; 2-Methylphenol, analytical standard; 2,3,4,6-Tetrachlorophenol; Pentachlorophenol; 4-Nitrophenol; 2-Bromophenol; 2,3,5,6-Tetrachlorophenol; 2,3,5-Trichlorophenol; 4-Chloro-3-methylphenol; 2,4,5-Trichlorophenol; 4-Methylphenol, analytical standard; 2,4-Dimethylphenol; 2-Nitrophenol; 3-Methylphenol, analytical standard; Phenol; 2-Methyl-4,6-dinitrophenol; 2,3,4-Trichlorophenol; 2,6-Dichlorophenol; 2,3,4,5-Tetrachlorophenol

Protocols

GC Analysis of Phenols in Water on a 5% Phenyl Column after SPE using Supelclean™ ENVI-Chrom P

Separation of 2-Nitrophenol; Pentachlorophenol; 2-Bromophenol; Phenol; 4-Nitrophenol; 3-Methylphenol, analytical standard; 4-Chloro-3-methylphenol; 2,4-Dichlorophenol; 2,3,4,6-Tetrachlorophenol; 2-Methylphenol, analytical standard; 2,4,6-Trichlorophenol; 2,4-Dimethylphenol; 2-Chlorophenol

HPLC Analysis of Phenols on SUPELCOSIL™ LC-8

HPLC Analysis of Phenols on SUPELCOSIL™ LC-8

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