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Safety Information

C011

Sigma-Aldrich

cis-2-Methyl-5-trimethylammoniummethyl-1,3-oxathiolane iodide

Synonym(s):

OXA-22

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About This Item

Empirical Formula (Hill Notation):
C8H18INOS
CAS Number:
76541-57-6
Molecular Weight:
303.20
MDL number:
MFCD00069222
UNSPSC Code:
12352100
PubChem Substance ID:
57653973
NACRES:
NA.22

color

yellow

solubility

H2O: soluble
methanol: soluble

SMILES string

[I-].C[C@H]1O[C@H](CS1)C[N+](C)(C)C

InChI

1S/C8H18NOS.HI/c1-7-10-8(6-11-7)5-9(2,3)4;/h7-8H,5-6H2,1-4H3;1H/q+1;/p-1/t7-,8-;/m0./s1

InChI key

TWNAKQKXXMGYQT-WSZWBAFRSA-M

Gene Information

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

Biochem/physiol Actions

Potent muscarinic acetylcholine receptor agonist.

Caution

Photosensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

C011-25MG:
C011-VAR:
C011-BULK:
C011-5MG:4548173996196

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Certificates of Analysis (COA)

Lot/Batch Number
107H4612V

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R M Eglen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 342(4), 394-399 (1990-10-01)
1. para-Fluoro-hexahydrosila-difenidol (p-F-HHSiD) has been proposed as an M3 selective antagonist. However, the M3 selectivity is variable in that it exhibits a high pA2 value for M3 muscarinic receptors in guinea-pig ileum but a low value at muscarinic receptors in
Zizhuo Su et al.
American journal of translational research, 12(7), 3964-3973 (2020-08-11)
Cyclophilin A (CyPA) plays an important role in the progression of atherosclerosis. Additionally, it has been reported that lysosomal function is markedly impaired in atherosclerosis induced by oxidized low-density lipoprotein (ox-LDL). As the CyPA degradation pathway remains to be elucidated
P Angeli et al.
British journal of pharmacology, 85(4), 783-786 (1985-08-01)
The efficacy and affinity of nine pentatomic cyclic muscarinic agonists were determined on the guinea-pig ileum, according to the method of Furchgott & Bursztyn (1967). The efficacy and affinity of these agonists are affected differently by structural modifications. Our results

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