937266
NanoFabTx™ for gene delivery
Maleimide lipid mix
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General description
This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of lipid nanoparticles. Step-by-step protocols for the synthesis of maleimide-functionalized LNPs by microfluidics with the NanoFabTx™ microfluidic- nano device kit (Cat. No. 911593) or nanoprecipitiation are included.
Maleimide-functionalized LNPs are particularly advantageous for gene delivery because the maleimide functional group enables the conjugation of thiol-containing antibodies, proteins, aptamers, or other molecules to the lipid nanoparticle surface. This can be used for multi-targeting or multi-type cargo delivery to different cell types including immune cells, making it advantageous for many different therapuetic applications including mRNA vaccine delivery and oncology.
Application
Features and Benefits
- A ready-to-use nanoformulation lipid blend to synthesize Maleimide-functionalized lipid nanoparticles
- Step-by-step protocols developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible lipid nanoparticles
- Optimized to make lipid nanoparticles around 100 nm with low polydispersity
- Optimized lipid blend for thiol-containing protein or antibody conjugation
- Optimized lipid blend for Maleimide-functionalized lipid nanoparticles for mRNA encapsulation
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
937266-20MG-PW:
937266-20MG:
937266-BULK:
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