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937185

Sigma-Aldrich

Polysuccinimide

≥95%, average Mw 60000

Synonym(s):

PSI

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About This Item

Linear Formula:
(C4H3NO2)n
CAS Number:
31586-29-5
UNSPSC Code:
12352142
NACRES:
NA.21

Agency

suitable for controlled release

Quality Level

100

Assay

≥95%

form

powder or chunks

mol wt

average Mw 60000

color

white to light brown

application(s)

advanced drug delivery
agriculture
cosmetics

General description

Polysuccinimide (PSI), commonly synthesized through thermal polymerization, is a polyimide precursor for the production of such biocompatible and degradable polymers namely polyaspartic acid and various polyaspartamides. Polyaspartic acid is produced by hydrolysis of PSI under alkaline condition while polyaspartamide is produced by ring opening of PSI using a nucleophilic reagent. The presence of amide linkages in these polymers gives them peptide-like structures which is prone to hydrolysis and subsequent degradation. These derivatives could be potential substitutes for different polyamino acids in many medical applications.

Application

Polysuccinimide (PSI) has been used for a variety of applications including:
  • As a nanocarrier or microcarrier delivery vehicle in pharmaceutical, cosmetic, and agriculture (agrochemical) fields
  • As electrospun fibers, films, meshes or mats for wound healing applications
  • As nanofibers for electronic and biosensor applications
  • As a sustainable and environmentally friendly alternative to non-degradable polymers

Features and Benefits

  • Biodegradable by hydrolysis allowing for sustained and controlled delivery
  • High swelling ratio with superabsorbent properties
  • Water soluble
  • Peptide-like and biocompatible

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

937185-VAR:
937185-1G:
937185-BULK:

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