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Safety Information

934372

Sigma-Aldrich

MC-Val-Cit-PAB-PNP

≥95%

Synonym(s):

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-

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About This Item

Empirical Formula (Hill Notation):
C35H43N7O11
CAS Number:
159857-81-5
Molecular Weight:
737.76
Beilstein:
10322169
MDL number:
MFCD22200431
UNSPSC Code:
12352200
PubChem Substance ID:
468592337
NACRES:
NA.22
form:
powder
Assay:
≥95%

Quality Level

100

Assay

≥95%

form

powder

storage temp.

2-8°C

SMILES string

[N+](=O)([O-])c1ccc(cc1)OC(=O)OCc2ccc(cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCCN3C(=O)C=CC3=O)C(C)C)CCCNC(=O)N

Application

This is a bifunctional cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC).

Features and Benefits

The maleimide functionality can be used for bioconjugation to thiols in monoclonal antibodies while the activated carbonate esters can be used for construction of carbamate linkages with amine containing payloads.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

934372-VAR:
934372-BULK:
934372-50MG:

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