Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

933554

Sigma-Aldrich

NanoFabTx NTA Lipid Mix

for synthesis of NTA-functionalized liposomes for small molecule delivery

Synonym(s):

Cholesterol, DGS-NTA(Ni), HSPC, PEG-DSPE

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352211
NACRES:
NA.21

Quality Level

storage temp.

−20°C

Application

NanoFabTx NTA Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of NTA-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with NTA groups using extrusion and microfluidics are also included. The synthesized NTA-functionalized liposomes enable the conjugation of His-tagged antibodies or proteins to the liposomes surface for immunothereapy applications and multi-targeting or multi-type cargo delivery.

Features and Benefits

  • A ready-to-use nanoformulation lipid blend for the synthesis of NTA-functionalized liposomes
  • Step-by-step extrusion and microfluidics protocols for liposome synthesis developed and tested by our formulation scientists
  • Flexible synthesis methods to create uniform and reproducible liposomes
  • Protocols and lipid blend optimized to make liposomes around 100 nm diameter with low polydispersity
  • Lipid mix optimized for His-tagged protein or antibody conjugation and small molecule encapsulation
Comprehensive protocols for liposome synthesis are included:
  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
TMAX is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

933554-100MG-PW:
933554-25MG:
933554-25MG-PW:
933554-BULK:
933554-100MG:
933554-VAR:


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mesoscale active matter in fluids
Klotsa, Daphne
Soft Matter (2019)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service